Zj7923

Chemical Structure : Zj7923

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货号: PC-24784Not For Human Use, Lab Use Only.

Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1.

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生物&药学活性

Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1.
Zj7923 could increase the spontaneous firing rate of normal hippocampal pyramidal neurons and ameliorate OGD-induced impairment of neuronal excitability.
Zj7923 provides protection against DTDP-induced apoptosis and its mechanism might be related to the modulation of the expression of apoptosis-related proteins, such as Bcl-2, Bax and cleaved caspase-3 proteins.
Zj7923 significantly reduces infarct volume and improved neurological deficits in rats following transient middle cerebral artery occlusion.

物理化学性质&存储条件

分子量	383.49
分子式	C22H29N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-ethoxy-5-isobutyramido-N-(1-(3-(methylamino)phenyl)ethyl) benzamide

参考文献

1. Tianjiao Yang, et al. Neuropharmacology. 2025 May 29:278:110537.

Zj7923

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Zj7923

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