Zinilisib (OKI-219) | PI3Kα H1047R inhibitor | Probechem Biochemicals

Chemical Structure : Zinilisib

加入收藏

Zinilisib (OKI-219, OKI 219)

货号: PC-28524Not For Human Use, Lab Use Only.

Zinilisib (OKI-219) is a potent, highly mutant-selective, brain penetrant and orally bioavailable inhibitor of PI3kα H1047 mutant, 100-fold selectivity for PI3KαH1047R over PI3KαWT.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Zinilisib (OKI-219) is a potent, highly mutant-selective, brain penetrant and orally bioavailable inhibitor of PI3kα H1047 mutant, 100-fold selectivity for PI3KαH1047R over PI3KαWT.
OKI-219 drives decreased phosphorylated AKT (pAKT) and decreased proliferation selectively in PI3KαH1047R mutant cell lines across several tumor types.
OKI-219 is active as a single agent in breast tumor models that have the PI3KαH1047R mutation.
OKI-219 is highly active in preclinical models of PI3KαH1047R-mutated cancer, including models of CNS disease, without the toxicities associated with wild-type inhibition.

物理化学性质&存储条件

分子量	502.54
分子式	C26H29F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((1-(2,7-dimethyl-1-oxo-3-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)-1,2-dihydroisoquinolin-5-yl)ethyl)amino)benzoic acid

参考文献

1. Molly A Taylor, et al. Mol Cancer Ther (2023) 22 (12_Supplement): B163.

2. James F, et al. WO2024054469A1. WIPO (PCT). 2023-09-06.

Zinilisib (OKI-219, OKI 219)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Zinilisib (OKI-219, OKI 219)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.