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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Zinc Pyrithione
Zinc Pyrithione

Chemical Structure : Zinc Pyrithione

CAS No.: 13463-41-7

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Zinc Pyrithione (Zn-Pyrithione)

货号: PC-27790Not For Human Use, Lab Use Only.

Zinc pyrithione (Zn-Pyrithione, ZnPy) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump, potentiates potassium currents induced by KCNQ homomultimers, show agonistic activity for KCNQ channels, potently activates both heterologous and native M channels by inducing channel opening at the resting potential, also is a copper ionophore.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zinc pyrithione (Zn-Pyrithione, ZnPy) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump, potentiates potassium currents induced by KCNQ homomultimers, show agonistic activity for KCNQ channels, potently activates both heterologous and native M channels by inducing channel opening at the resting potential, also is a copper ionophore.

物理化学性质&存储条件

分子量 317.69
分子式 C10H8N2O2S2Zn
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[O-][N+]1=C(C=CC=C1)S[Zn]SC2=[N+]([O-])C=CC=C2

参考文献

1. Yang-Ming Zhang, et al. J Med Chem. 2021 May 13;64(9):5816-5837.

2. Qiaojie Xiong, et al. Nat Chem Biol. 2007 May;3(5):287-96.

3. Ermolayeva, E. et al. Appl Environ Microbiol, 1995. 61(9): p. 3385-90.

4. Peter Tsvetkov, et al. Science. 2022 Mar 18;375(6586):1254-1261.

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