Zifaxaban

Chemical Structure : Zifaxaban

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货号: PC-35604Not For Human Use, Lab Use Only.

Zifaxaban is a novel, potent, selective, direct and oral factor Xa (FXa) inhibitor with IC50 of 11.1 nM (human FXa), displays >10,000-fold selectivity than other serine proteases.

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生物&药学活性

Zifaxaban is a novel, potent, selective, direct and oral factor Xa (FXa) inhibitor with IC50 of 11.1 nM (human FXa), displays >10,000-fold selectivity than other serine proteases.
Zifaxaban also deoes not impair platelet aggregation induced by collagen, adenosine diphosphate (ADP) or arachidonic acid.
Zifaxaban significantly prolongs clotting time, prothrombin time (PT), and activated partial thromboplastin time (APTT) in the plasma of humans, rabbits, and rats, with a relatively weak effect on thrombin time.
Zifaxaban strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg in venous thrombosis models in rats.

物理化学性质&存储条件

分子量	429.875
分子式	C20H16ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-chloro-N-((2-oxo-3-(4-(2-oxopyridin-1(2H)-yl)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

参考文献

1. Qiu X, et al. Eur J Pharmacol. 2018 Aug 17. pii: S0014-2999(18)30469-2.

Zifaxaban

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物理化学性质&存储条件

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Zifaxaban

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