Zibotentan (ZD4054) | ETA receptor inhibitor | Probechem Biochemicals

Chemical Structure : Zibotentan

CAS No.: 186497-07-4

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Zibotentan (ZD4054, ZD-4054)

货号: PC-42282Not For Human Use, Lab Use Only.

Zibotentan (ZD4054) is an orally active, specific Endothelin A receptor (ETA) inhibitor with Ki of 13 nM, shows anticancer effects.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2480	In stock
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生物&药学活性

Zibotentan (ZD4054) is an orally active, specific Endothelin A receptor (ETA) inhibitor with Ki of 13 nM, shows anticancer effects.
Zibotentan (ZD4054) specifically inhibits ETA-mediated antiapoptotic effects, but not ETB-mediated proapoptotic effects in human smooth muscle cells.
Zibotentan (ZD4054) inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo.

物理化学性质&存储条件

分子量	424.4331
分子式	C19H16N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyridinesulfonamide, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-

参考文献

1. Morris CD, et al. Br J Cancer. 2005 Jun 20;92(12):2148-52.

2. Bradbury RH, et al. J Med Chem. 1997 Mar 14;40(6):996-1004.

3. Carducci MA, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6296s-6300s.

4. Rosanò L, et al. Mol Cancer Ther. 2007 Jul;6(7):2003-11.

Zibotentan (ZD4054, ZD-4054)

生物&药学活性

物理化学性质&存储条件

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Zibotentan (ZD4054, ZD-4054)

生物&药学活性

物理化学性质&存储条件

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