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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Guanylate Cyclase-Zagociguat
Zagociguat

Chemical Structure : Zagociguat

CAS No.: 2201048-82-8

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Zagociguat (CY-6463, CY6463, IW-6463, IW6463)

货号: PC-73456Not For Human Use, Lab Use Only.

Zagociguat (CY6463) is a potent, selective, brain-penetrant and orally-active soluble guanylate cyclase (sGC) activator with EC50 of 66 nM in cell-based cGMP asssays.

规格 价格 库存 数量
5 mg ￥2280 In stock
10 mg ￥3680 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zagociguat (CY6463) is a potent, selective, brain-penetrant and orally-active soluble guanylate cyclase (sGC) activator with EC50 of 66 nM in cell-based cGMP asssays.
Zagociguat (CY6463) stimulates the phosphorylation of CREB in a concentration-dependent fashion in rat primary neurons with EC50 of 25.7 nM.
Zagociguat (CY6463) elicits decreases in blood pressure in both rats and mice.
Zagociguat (CY6463) improves cognitive performance in a model of cognitive disruption induced by the administration of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist.
Zagociguat (CY6463) increases long-term potentiation (LTP) in hippocampal slices from a Huntington's disease mouse model and decreases the loss of dendritic spines in aged and Alzheimer's disease mouse models.

物理化学性质&存储条件

分子量 362.292
分子式 C16H10F4N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Imidazo[1,2-a]pyrazine, 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]-

参考文献

1. Correia SS, et al. Front Pharmacol. 2021 May 24;12:656561.

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