ZYDG2 calcium salt

Chemical Structure : ZYDG2 calcium salt

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货号: PC-24516Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ZYDG2 hemicalcium salt is a potent and selective agonist for GPR40 (FFAR1) with EC50 of 41 nM and 17 nM in cell-based functional inositol 1-phosphate-ELISA assay and Ca2+ mobilization assay, respectively.
ZYDG2 demonstrates dose-dependent improvement in glucose tolerance tests and increased insulin secretion in neonatal streptozotocin Wistar rats.
ZYDG2 significantly increased the glucose infusion rate in a hyperglycemic clamp study and demonstrated antidiabetic efficacy in mice models of type 2 diabetes mellitus.
ZYDG2 is a highly promising and unequivocally safe therapeutic candidate for the treatment of type 2 diabetes.

物理化学性质&存储条件

分子量	849.05
分子式	C50H52CaN2O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	calcium (3S)-3-(4-((3-((6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)methyl)benzyl)oxy)phenyl)hex-4-ynoate

参考文献

1. Jain MR, et al. J Pharmacol Exp Ther. 2025 Mar 6;392(4):103534.