ZY341

Chemical Structure : ZY341

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货号: PC-24398Not For Human Use, Lab Use Only.

ZY341 is a potent small molecule PERK agonist with SPR Kd value of 17.5 uM, exhibits robust activity in effectively mitigating myocardial ischemia-reperfusion injury.

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生物&药学活性

ZY341 is a potent small molecule PERK agonist with SPR Kd value of 17.5 uM, exhibits robust activity in effectively mitigating myocardial ischemia-reperfusion injury.
ZY341 activates the PERK/eIF2α pathway and alleviates cardiomyocyte apoptosis.
ZY341 (10 mg/kg, 30 mg/kg i.p.) protects the heart from reperfusion injury in vivo, represses the expression of c-caspase3 and c-caspase3/total caspase3 in a dose manner.
ZY341 protects the structural homeostasis of mitochondria.
ZY341 alleviates the excessive production of MAM induced by hypoxia reperfusion.
ZY341 (30 mg/kg, i,p.) significantly reduced the expression level of PTPIP51 in mouse cardiac tissue, inhibited the upregulation of PTPIP51 in the OGD/R model, inhibited the abnormal generation of MAMs.
ZY341 promotes the accumulation of mitochondrial PA, which improves the mitochondrial structure and function.

物理化学性质&存储条件

分子量	409.44
分子式	C22H23N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-ethoxy-4-formylphenoxy)acetamide

参考文献

1. Li Z, et al. Int J Cardiol. 2025 Apr 4:133222.

ZY341

生物&药学活性

物理化学性质&存储条件

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ZY341

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物理化学性质&存储条件

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