ZY-19489 | Antimalarial | Probechem Biochemicals

Chemical Structure : ZY-19489

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ZY-19489 (Zintrodiazine, Sutidiazine, MMV 253, AZ13721412)

货号: PC-25005Not For Human Use, Lab Use Only.

Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is a novel antimalarial triaminopyrimidine compound with IC50 of 9 nM against sexual blood stage of Plasmodium falciparum (Pf).

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生物&药学活性

Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is a novel antimalarial triaminopyrimidine compound with IC50 of 9 nM against sexual blood stage of Plasmodium falciparum (Pf).
Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is inactive in the P. berghei liver schizont assay (IC50 >10μM) as well as the P. cynomolgi liver schizont and hypnozoite assay (IC50 >10 μM).
Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is inactive in vitro activity in the Pf male and female dual gamete assay
Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is efficacious in a mouse model of Pf malaria with an ED99 <30 mg kg−1 and displays good in vivo safety margins in guinea pigs and rats.

物理化学性质&存储条件

分子量	465.58
分子式	C24H32FN9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N2-(4-cyclopropyl-5-fluoro-6-methylpyridin-2-yl)-N4-(1,5-dimethyl-1H-pyrazol-3-yl)-5-(3,4-dimethylpiperazin-1-yl)pyrimidine-2,4-diamine

参考文献

1. Barber BE, et al. Lancet Infect Dis. 2022 Jun;22(6):879-890.

2. Ghoghari AM, et al. Bioanalysis. 2021 Dec;13(23):1761-1777.

3. Hameed P S, et al. Nat Commun. 2015 Mar 31;6:6715.

ZY-19489 (Zintrodiazine, Sutidiazine, MMV 253, AZ13721412)

生物&药学活性

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ZY-19489 (Zintrodiazine, Sutidiazine, MMV 253, AZ13721412)

生物&药学活性

物理化学性质&存储条件

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