ZSTK3744 | AhR agonist | Probechem Biochemicals

Chemical Structure : ZSTK3744

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ZSTK3744 (ZSTK-3744)

货号: PC-26116Not For Human Use, Lab Use Only.

ZSTK3744 is a small molecule Aryl hydrocarbon receptor (AhR) agonist, exhibits cell growth inhibitory activity with IC50 of 0.87 nM for chemotherapy-resistant TNBC MDA-MB-468 cells.

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生物&药学活性

ZSTK3744 is a small molecule Aryl hydrocarbon receptor (AhR) agonist, exhibits cell growth inhibitory activity with IC50 of 0.87 nM for chemotherapy-resistant TNBC MDA-MB-468 cells.
ZSTK3744 exerts its cell growth-inhibitory activity through an apoptosis-mediated mechanism.
ZSTK3744 demonstrates more potent efficacy than adriamycin, paclitaxel, and eribulin in chemotherapy-resistant cells.
ZSTK3744 significantly reduces the viability of MM468, MM453, and DU4475 cells.
ZSTK3744 induces CYP1A1 and CYP1B1 mRNA expression in MM468, MM453, and DU4475 cells.
ZSTK3744 administration at 2.5 and 5 mg/kg significantly reduced the tumor volume in MM468-transplanted mice.

物理化学性质&存储条件

分子量	381.44
分子式	C22H19N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-7-methyl-2-(4-methyl-1H-benzo[d]imidazol-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

参考文献

1. Takahiro Ohashi, et al. Cancer Res Commun. 2026 Feb 1;6(2):421-436.

ZSTK3744 (ZSTK-3744)

生物&药学活性

物理化学性质&存储条件

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ZSTK3744 (ZSTK-3744)

生物&药学活性

物理化学性质&存储条件

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