ZQ105 | C5aR2 agonist | Probechem Biochemicals

Chemical Structure : ZQ105

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ZQ105 (ZQ-105, Ac-His-Arg-Pro-DCha-Nal-Darg)

货号: PC-27245Not For Human Use, Lab Use Only.

ZQ105 is a potent, highly selective complement receptor C5aR2 agonist with KD of 1.25 uM, does not activate C5aR1, induces β-arrestin1 recruitment to C5aR2 with pEC50 of 6.02.

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生物&药学活性

ZQ105 is a potent, highly selective complement receptor C5aR2 agonist with KD of 1.25 uM, does not activate C5aR1, induces β-arrestin1 recruitment to C5aR2 with pEC50 of 6.02.
ZQ105 showsno activity toward C3aR, a complement receptor activated by C3a.
ZQ105 increases intracellular reactive oxygen species (ROS) production, upregulated CD11b expression, and enhanced LPS-induced IL-6 production in human neutrophils.
ZQ105 selectively enhances surface expression of CD10 and LPS-induced IL-1β production in neutrophils.
ZQ105 induces significant reduction in surface expression of C5aR2 in human neutrophils.
ZQ105 induces marked perinuclear redistribution and increased fluorescence intensity of the endosomal and lysosomal markers EEA1, RAB7, and LAMP1, indicating that C5aR2 activation modulates endo-lysosomal organization.

物理化学性质&存储条件

分子量	929.14
分子式	C47H68N12O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((S)-2-((R)-2-((S)-1-(acetyl-L-histidyl-L-lysyl)pyrrolidine-2-carboxamido)-3-cyclohexylpropanamido)-3-(naphthalen-1-yl)propanoyl)-L-arginine

参考文献

1. Jiao Qin, et al. Cell Res. 2026 Jul 3. doi: 10.1038/s41422-026-01273-1.

ZQ105 (ZQ-105, Ac-His-Arg-Pro-DCha-Nal-Darg)

生物&药学活性

物理化学性质&存储条件

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ZQ105 (ZQ-105, Ac-His-Arg-Pro-DCha-Nal-Darg)

生物&药学活性

物理化学性质&存储条件

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