ZM-447439 |CAS:331771-20-1 Probechem Biochemicals

Chemical Structure : ZM-447439

CAS No.: 331771-20-1

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ZM-447439 (ZM447439;ZM 447439)

货号: PC-42348Not For Human Use, Lab Use Only.

ZM-447439 is a potent, selective dual Aurora A and Aurora B inhibitor with IC50 of 110 and 130 nM, respectively.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

ZM-447439 is a potent, selective dual Aurora A and Aurora B inhibitor with IC50 of 110 and 130 nM, respectively.
ZM-447439 prevents anaplastic thyroid cancer cell growth and tumorigenicity, inhibits the growth and tumorigenicity of a panel of ATC derived cell lines (CAL-62, 8305C, 8505C and BHT-101) with IC50 of 0.5-5 uM.
ZM447439-treated cells exit mitosis with normal kinetics, accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint.

物理化学性质&存储条件

分子量	513.5875
分子式	C29H31N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-

参考文献

1. Baldini E, et al. J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):705-15.

2. Gadea BB, et al. Mol Biol Cell. 2005 Mar;16(3):1305-18.

3. Ditchfield C, et al. J Cell Biol. 2003 Apr 28;161(2):267-80.

4. Lane SI, et al. Reproduction. 2010 Oct;140(4):521-30.

ZM-447439 (ZM447439;ZM 447439)

生物&药学活性

物理化学性质&存储条件

参考文献

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ZM-447439 (ZM447439;ZM 447439)

生物&药学活性

物理化学性质&存储条件

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