ZLWH-60 | GSK3β inhibitor | Probechem Biochemicals

Chemical Structure : ZLWH-60

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ZLWH-60 (ZLWH60)

货号: PC-28133Not For Human Use, Lab Use Only.

ZLWH-60 is a potent GSK3β inhibitor with IC50 of 11.5 nM, inhibits phosphorylation of tau protein in Tau (P301L) 293 T cell, SH-SY5Y cell and HT22 cell.

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生物&药学活性

ZLWH-60 is a potent GSK3β inhibitor with IC50 of 11.5 nM, inhibits phosphorylation of tau protein in Tau (P301L) 293 T cell, SH-SY5Y cell and HT22 cell.
ZLWH-60 inhibited GSK3β activity and reduced tau hyperphosphorylation in OKA induced HT22 cell models.
ZLWH-60 downregulates LPS-evoked proinflammatory cytokine in BV2 microglial cells.
ZLWH-60 (2.5-5 mg/kg) ameliorated AD symptoms in OKA-induced mice, significantly decreased OKA-mediated tau hyperphosphorylation in wild-type mice.
ZLWH-60 significantly diminishes LPS-mediated proinflammatory cytokine levels and Iba-1 fluorescence intensity, significantly decreases LPS-mediated neuronal damage.

物理化学性质&存储条件

分子量	418.88
分子式	C23H19ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chlorobenzyl)-1-(cyclopropanecarboxamido)-9H-pyrido[3,4-b]indole-7-carboxamide

参考文献

1. Ning XY, et al. Neurochem Int. 2026 Jan;192:106090.

ZLWH-60 (ZLWH60)

生物&药学活性

物理化学性质&存储条件

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ZLWH-60 (ZLWH60)

生物&药学活性

物理化学性质&存储条件

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