ZLWH-23 | AChE/GSK-3β inhibitor | Probechem Biochemicals

Chemical Structure : ZLWH-23

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ZLWH-23 (ZLWH23)

货号: PC-28135Not For Human Use, Lab Use Only.

ZLWH-23 is a selective acetylcholinesterase (AChE) inhibitor with IC50 of 0.27 uM, also inhibits glycogen synthase kinase-3 (GSK-3β) with IC50 of 6.78 uM, possesses selectivity for AChE over BChE and for GSK-3β over multi-kinases.

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100 mg		Get quote

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生物&药学活性

ZLWH-23 is a selective acetylcholinesterase (AChE) inhibitor with IC50 of 0.27 uM, also inhibits glycogen synthase kinase-3 (GSK-3β) with IC50 of 6.78 uM, possesses selectivity for AChE over BChE and for GSK-3β over multi-kinases.
ZLWH-23 has very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines.
ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model.

物理化学性质&存储条件

分子量	513.62
分子式	C30H32FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9H-Pyrido[3,4-b]indole-7-carboxamide, 1-[(cyclopropylcarbonyl)amino]-N-[2-[1-[(2-fluorophenyl)methyl]-4-piperidinyl]ethyl]-

参考文献

1. Liu W, et al. Eur J Med Chem. 2022;229:114095.

ZLWH-23 (ZLWH23)

生物&药学活性

物理化学性质&存储条件

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ZLWH-23 (ZLWH23)

生物&药学活性

物理化学性质&存储条件

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