ZK-14i | Skp2 inhibitor | Probechem Biochemicals

Chemical Structure : ZK-14i

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ZK-14i (Skp2 inhibitor 14i)

货号: PC-24706Not For Human Use, Lab Use Only.

ZK-14i (Skp2 inhibitor 14i) is a potent inhibitor of S-phase kinase-associated protein 2 (Skp2) with IC50 of 2.8 uM against the Skp2-Cks1 interaction.

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生物&药学活性

ZK-14i (Skp2 inhibitor 14i) is a potent inhibitor of S-phase kinase-associated protein 2 (Skp2) with IC50 of 2.8 uM against the Skp2-Cks1 interaction.
ZK-14i has cell growth IC50 of 4.8 and 7.0 μM against PC-3 and MGC-803 cells, respectively.
ZK-14i exhibits effectively anticancer effects on PC-3 and MGC-803 xenograft mice models without obvious toxicity.

物理化学性质&存储条件

分子量	406.91
分子式	C23H23ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(1-(5,6-diphenylpyrazin-2-yl)piperidin-4-yl)acetamide

参考文献

1. Kun Zhang, et al. J Med Chem. 2023 Jun 8;66(11):7221-7242.

ZK-14i (Skp2 inhibitor 14i)

生物&药学活性

物理化学性质&存储条件

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ZK-14i (Skp2 inhibitor 14i)

生物&药学活性

物理化学性质&存储条件

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