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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-ZJC-11
ZJC-11

Chemical Structure : ZJC-11

CAS No.:

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ZJC-11 (ZJC11)

货号: PC-27634Not For Human Use, Lab Use Only.

ZJC-11 is a potent, selective and covalent cyclin-dependent kinase 7 (CDK7) inhibitor with IC50 of 5.4 nM, has >100-fold selectivity over CDK1/2/9.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZJC-11 is a potent, selective and covalent cyclin-dependent kinase 7 (CDK7) inhibitor with IC50 of 5.4 nM, has >100-fold selectivity over CDK1/2/9.
ZJC-11 not only suppresses transcription and G2/M cell cycle checkpoint pathways but also induces DNA damage-driven cellular senescence, ultimately leading to TNBC cell death.
ZJC-11 not only exhibited a synergistic anti-TNBC effect when combined with doxorubicin but also alleviated doxorubicin-induced cardiotoxicity.

物理化学性质&存储条件

分子量 542.04
分子式 C29H28ClN7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-(3-((5-chloro-4-(phenylamino)pyrimidin-2-yl)amino)phenyl)-3-(4-(dimethylamino)but-2-enamido)benzamide

参考文献

1. Chen B, et al. J Med Chem. 2026 Aug 13;69(15):18364-18385.

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