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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-ZINC02092166
ZINC02092166

Chemical Structure : ZINC02092166

CAS No.: 354543-09-2

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ZINC02092166 (ZINC 02092166)

货号: PC-61803Not For Human Use, Lab Use Only.

ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively。
ZINC02092166 remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM。
ZINC02092166 exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs.

物理化学性质&存储条件

分子量 349.27
分子式 C14H7N9O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-4-amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide

参考文献

1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92.

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