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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-ZG-2686
ZG-2686

Chemical Structure : ZG-2686

CAS No.: 1795110-22-3

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ZG-2686 (ZG2686)

货号: PC-26180Not For Human Use, Lab Use Only.

ZG-2686 is a potent HIF-2α agonist with EC50 of 0.25 uM, Emax=375.7%, synergistically enhances HIF-2α-dependent EPO gene expression when combined with prolyl hydroxylase domain (PHD) inhibitor Vadadustat.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZG-2686 is a potent HIF-2α agonist with EC50 of 0.25 uM, Emax=375.7%, synergistically enhances HIF-2α-dependent EPO gene expression when combined with prolyl hydroxylase domain (PHD) inhibitor Vadadustat.

物理化学性质&存储条件

分子量 317.15
分子式 C13H9BrN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-bromo-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)benzamide

参考文献

1. Yinli Gao, et al. J Med Chem. 2025 Dec 11;68(23):25569-25589.

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