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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Lactate Dehydrogenase (LDH)-ZG-2492
ZG-2492

Chemical Structure : ZG-2492

CAS No.: 3084810-37-4

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ZG-2492 (ZG2492)

货号: PC-24993Not For Human Use, Lab Use Only.

ZG-2492 is a potent, orally bioavailable inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 156 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZG-2492 is a potent, orally bioavailable inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 156 nM.
ZG-2492 exhibits cytotoxicity activity against pancreatic Mia PaCa-2 cells with IC50 of 2.4 uM, shows no toxicity to normal HUVEC cells (IC50>40 uM).
ZG-2492 inhibits lactate production in pancreatic Mia PaCa-2 cells with IC50 of 3.6 uM.
ZG-2492 binds LDHA with a dissociation constant (Kd) of 3.99 μM in SPR assays.
ZG-2492 (1-10 uM) induces apoptosis in Mia PaCa-2 cells. 
ZG-2492 (100 mg/kg, oral) exhibited antitumor effects in Mia PaCa-2 xenograft nude mouse model.

物理化学性质&存储条件

分子量 448.92
分子式 C20H21ClN4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-(3-(N-(2-Chloro-5-cyanophenyl)sulfamoyl)phenyl)piperazin-1-yl)propanoic Acid

参考文献

1. Qijie Gong, et al. J Med Chem. 2025 Jul 11. doi: 10.1021/acs.jmedchem.5c00359.

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