ZG-2033

Chemical Structure : ZG-2033

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货号: PC-24483Not For Human Use, Lab Use Only.

ZG-2033 is a potent, selective and orally bioavailable HIF-2α agonist with EC50 of 490 nM, Emax = 349.2%.

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生物&药学活性

ZG-2033 is a potent, selective and orally bioavailable HIF-2α agonist with EC50 of 490 nM, Emax = 349.2%.
ZG-2033 strengthens the dimerization of HIF-2α and ARNT.
ZG-2033 increases the expression of HIF-2 downstream genes─such as EPO, VEGF, GLUT1, and Cyclin D1─in a concentration-dependent manner in 786-O cells, increases EPO expression by 1.57 times at a concentration of 10 μM.
ZG-2033 combined with PHD inhibitor AKB-6548 exhibits a synergistic effect in doxorubicin-induced zebrafish anemia.

物理化学性质&存储条件

分子量	286.35
分子式	C15H14N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2-Benzisothiazol-3-amine, N-(3,5-dimethoxyphenyl)-

参考文献

1. Yu Y, et al. J Med Chem. 2021 Dec 9;64(23):17384-17402.

ZG-2033

生物&药学活性

物理化学性质&存储条件

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ZG-2033

生物&药学活性

物理化学性质&存储条件

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