ZDLT-1 (ZDLT1)| HDAC inhibitor | Probechem Biochemicals

Chemical Structure : ZDLT-1

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ZDLT-1 (ZDLT1)

货号: PC-28434Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ZDLT-1 is potent HDAC inhibitor with high inhibitory activity for class I HDACs 1, 2, and 3 with IC50 of 2.2-3.4 nM, shows potent anti-proliferative activity against HCT116 cells with IC50 of 0.173 uM.
ZDLT-1 does not inhibit HDAC8 (IC50>600 nM).
ZDLT-1 also exhibits better inhibitory activity with an IC50 value of 6 nM for HDAC6 than SAHA (IC50 = 15 nM).
ZDLT-1 induces apoptosis and inhibits cell migration in HCT116 cells.
ZDLT-1 can suppresse CRC cell growth in vivo and in vitro by triggering HIF-1α/Caspase-3/Caspase-9 pathway in promoting apoptosis, and triggering NF-κB/GSDMD/GSDME pathway in inhibiting tumor inflammation.

物理化学性质&存储条件

分子量	495.46
分子式	C25H20F3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-5-(5-(1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)-1,3,4-oxadiazol-2-yl)pentanamide

参考文献

1. Tian C, et al. Bioorg Med Chem Lett. 2022 May 15;64:128663.

2. Geng H, et al. Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113333.

ZDLT-1 (ZDLT1)

生物&药学活性

物理化学性质&存储条件

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ZDLT-1 (ZDLT1)

生物&药学活性

物理化学性质&存储条件

参考文献

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