zDHHC2 inhibitor TTZ1 (Tetrazole-1, TTZ-1) | zDHHC2 inhibitor

Chemical Structure : ZDHHC2 inhibitor TTZ1

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ZDHHC2 inhibitor TTZ1 (Tetrazole-1)

货号: PC-25634Not For Human Use, Lab Use Only.

zDHHC2 inhibitor TTZ1 (Tetrazole-1, TTZ-1) is a specific enzymatic inhibitor of palmitoyltransferase ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 4.7 uM.

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生物&药学活性

zDHHC2 inhibitor TTZ1 (Tetrazole-1, TTZ-1) is a specific enzymatic inhibitor of palmitoyltransferase ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 4.7 uM.
TTZ-1 inhibits zDHHC2-mediated SNAP25 S-acylation in cells with IC50 of 15 uM in HEK293T cells transfected with plasmids encoding GFP-tagged SNAP25b and HA-tagged zDHHC2.
TTZ-1 shows no effect on S-acylation of SNAP25 by zDHHC3 and zDHHC7.
TTZ-1 (25 uM) significantly inhibits PSD95-mCHERRY S-acylation by zDHHC2 and zDHHC15 in HEK293T cells.
TTZ-1 restores ACSL4 protein, reactivates ferroptosis, and reverses enzalutamide resistance in CRPC cell lines and patient-derived xenograft models.

物理化学性质&存储条件

分子量	436.52
分子式	C23H28N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-tetrazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)-4-(heptyloxy)benzamide

参考文献

1. Salaun C, et al. J Biol Chem. 2022 Oct;298(10):102469.

2. Shao S, et al. Adv Sci (Weinh). 2025 Oct 23:e14077.