ZD-1-186

Chemical Structure : ZD-1-186

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货号: PC-26240Not For Human Use, Lab Use Only.

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生物&药学活性

ZD-1-186 is a nondegradative molecular glue that downregulates MYC expression, brings together BCL6 with BRD9, a noncanonical BAF complex bromodomain protein implicated in maintaining MYC transcriptional output.
ZD-1-186 potently suppresses MYC and induces CDKN1A in a dose-dependent and electrophile-dependent manner.
ZD-1-186 binds BCL6 and covalently engages BRD9.
ZD-1-186 potently suppresses MYC and robustly induces CDKN1A (p21) in diffuse large B-cell lymphoma cells.

物理化学性质&存储条件

分子量	750.25
分子式	C35H37ClFN9O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(4-(5-chloro-4-((1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)piperazin-1-yl)-N-(3-fluoro-4-thiomorpholinophenyl)-4-oxobut-2-enamide

参考文献

1. Tuong Nghi Duong, et al. Discovery of Non-Degradative Covalent Molecular Glues for Transcriptional Reprogramming. bioRxiv [Preprint]. 2025 Dec 14:2025.12.12.694031.

ZD-1-186

生物&药学活性

物理化学性质&存储条件

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ZD-1-186

生物&药学活性

物理化学性质&存储条件

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