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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-ZAP-180013
ZAP-180013

Chemical Structure : ZAP-180013

CAS No.: 873080-25-2

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ZAP-180013 (ZAP180013)

货号: PC-38018Not For Human Use, Lab Use Only.

ZAP-180013 (ZAP180013) is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZAP-180013 (ZAP180013) is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).
ZAP-180013 inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.
ZAP-180013 also is a potent and selective inhibitor of NLRP3, interacts with histidine 698 (H698) in NLRP3.
ZAP-180013 effectively inhibits inflammasome activation in human myeloid cells, including those carrying MCC950-resistant NLRP3 mutations.
ZAP-180013 ameliorated psoriasiform skin inflammation and protected against lipopolysaccharide (LPS)-induced cytokine responses in mice.

物理化学性质&存储条件

分子量 454.32
分子式 C19H17Cl2N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide

参考文献

1. Patrick R Visperas, et al. SLAS Discov. 2017 Mar;22(3):324-331.
2. Kim W, et al. Cell Chem Biol. 2025 Sep 9:S2451-9456(25)00259-4.

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