Z1362873773

Chemical Structure : Z1362873773

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货号: PC-24544Not For Human Use, Lab Use Only.

Z1362873773 is a novel small molecule inhibitor of Fascin (FSCN1), reduces the fascin bundling activity.

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250 mg		Get quote

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生物&药学活性

Z1362873773 is a novel small molecule inhibitor of Fascin (FSCN1), reduces the fascin bundling activity.
Z1362873773 (400 uM) produced total inhibition of the formation of F-actin bundles.
Z1362873773 affects cancer cell viability with IC50 of 12.5 and 20.4 uM for DLD-1 and HCT-116 cells respectively.
Z1362873773 (20 uM, 24 & 48 hours) significantly reduced the migration of HCT-116 and DLD-1 cells.
Z1362873773 shows notably cytotoxic effect for primary (107T and 114T) and metastatic (06 M) colorectal cancer organoids.

物理化学性质&存储条件

分子量	365.35
分子式	C19H18F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopropyl-2,3-dihydroxy-4-methyl-N-(4-(trifluoromethyl)benzyl)benzamide

参考文献

1. Rodríguez-Martínez A, et al. Sci Rep. 2025 Apr 28;15(1):14906.

Z1362873773

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物理化学性质&存储条件

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Z1362873773

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物理化学性质&存储条件

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