Z-VAD-FMK | Caspase inhibitor | Probechem Biochemicals

Chemical Structure : Z-VAD-FMK

CAS No.: 161401-82-7

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货号: PC-24253Not For Human Use, Lab Use Only.

Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-known small molecule pan-caspase inhibitor and ICE-like protease inhibitor.

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生物&药学活性

Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-known small molecule pan-caspase inhibitor and ICE-like protease inhibitor.

Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos.

Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3.

Z-VAD-FMK decreases intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells.

分子量	453.47
分子式	C21H28FN3O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5S,8S,11S)-11-(2-Fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid

1. Davies CW, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. 2. Slee EA, et al. Biochem J. 1996 Apr 1;315 ( Pt 1)(Pt 1):21-4.