YTHu78

Chemical Structure : YTHu78

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货号: PC-24854Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

YTHu78 is a potent, selective CRBN ligand-based KDM5B PROTAC degrader, effectively induce KDM5B degradation in MV-4-11 and MM.1S cell lines, exhibits comparable degradation efficacy toward KDM5B and KDM5A.
YTHu78 effectively induces KDM5B protein degradation at a concentration of 0.74 μM in MV-4-11 cell line using Western blot analysis, YTHu78 depletes KDM5B in a time-dependent manner, with maximal degradation achieved after 12 h of treatment at a concentration of 5 μM.
YTHu78 utilizes a CRBN-mediated proteasome pathway for KDM5B degradation.
YTHu78 treatment induces apoptosis in MV-4-11 cells.
YTHu78 exhibits notable antiproliferative activity in HL60, MM.1S (IC50=1.036 uM), and OCI-AML3 cell lines.

物理化学性质&存储条件

分子量	632.64
分子式	C33H28N8O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dioxopiperidin-3-yl)-4-((3-(4-((4-((4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-2-yl)oxy)-1H-pyrazol-1-yl)methyl)phenyl)propyl)amino)isoindoline-1,3-dione

参考文献

1. Xiaowen Liu, et al. Eur J Med Chem. 2025 Jun 19:296:117883.

YTHu78

生物&药学活性

物理化学性质&存储条件

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YTHu78

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