YT-58 | BTK PROTAC | Probechem Biochemicals

Chemical Structure : YT-58

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YT-58 (RBBP7-recruiting BTK PROTAC degrader)

货号: PC-24930Not For Human Use, Lab Use Only.

YT-58 is a selective, RBBP7-recruiting BTK PROTAC degrader with DC50 of 0.17 uM (Dmax=83%), induces BTK degradation via the proteasome pathway and effectively inhibits BTK and PLCγ2 phosphorylation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

YT-58 is a selective, RBBP7-recruiting BTK PROTAC degrader with DC50 of 0.17 uM (Dmax=83%), induces BTK degradation via the proteasome pathway and effectively inhibits BTK and PLCγ2 phosphorylation.
Covalent modification of RBBP7 C97 is critical for YT-58-mediated BTK degradation.

物理化学性质&存储条件

分子量	706.87
分子式	C38H42N8O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(6-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)hexyl)-4-(N-ethynyl-N-methylsulfamoyl)benzamide

参考文献

1. Liu Y, et al. Angew Chem Int Ed Engl. 2025 Jul 2:e202508538.

YT-58 (RBBP7-recruiting BTK PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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YT-58 (RBBP7-recruiting BTK PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

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