YSR734 | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : YSR734

加入收藏

YSR734 (YSR-734, YSR 734)

货号: PC-21520Not For Human Use, Lab Use Only.

YSR734 is a first-in-class covalent HDACs inhibitor with IC50 of 0.109 uM, 0.154 uM and 0.143 uM for HDAC1, HDAC2, and HDAC3, sparing other deacetylases (HDAC4-HDAC10, IC50>10 uM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

YSR734 is a first-in-class covalent HDACs inhibitor with IC50 of 0.109 uM, 0.154 uM and 0.143 uM for HDAC1, HDAC2, and HDAC3, sparing other deacetylases (HDAC4-HDAC10, IC50>10 uM).
YSR734 shows weak activity against class IV HDAC11 (IC50 > 2000 nM).
YSR734 shows potent biological activity against MV4-11 and RS4;11 with IC50 of 0.53 and 1.00 uM, respectively, but not non-cancerous MRC-9 cells (IC50=20 uM).
YSR734 (0.5-5.0 uM) caused an increase in Ac-histone-H3 in MV4-11 cells, with no effect against Ac-α-tubulin (HDAC6), suggesting class I HDAC selectivity.
YSR734 (5 uM) potently induced myoblast differentiation as shown by upregulation of Cav3, myogenin, and Ac-α-tubulin, induced the formation of myotubes from myoblasts.

物理化学性质&存储条件

分子量	598.55
分子式	C26H23F5N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((perfluorophenyl)sulfonyl)piperidin-4-yl (4-((2-aminophenyl)carbamoyl)benzyl)carbamate

参考文献

1. Yasir S Raouf, et al. J Med Chem. 2023 Dec 7. doi: 10.1021/acs.jmedchem.3c01236.

YSR734 (YSR-734, YSR 734)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

YSR734 (YSR-734, YSR 734)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.