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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-YS-49
YS-49

Chemical Structure : YS-49

CAS No.: 132836-42-1

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YS-49 (YS49)

货号: PC-24778Not For Human Use, Lab Use Only.

YS-49 (YS49) is a small molecule PI3K activator and  positive inotropic isoquinoline compound.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YS-49 (YS49) is a small molecule PI3K activator and  positive inotropic isoquinoline compound.
YS 49 suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
YS-49 inhibits apoptosis in myocardial ischemia and reperfusion (I/R) injury in vivo via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and by reducing inflammation during I/R.

物理化学性质&存储条件

分子量 386.29
分子式 C20H20BrNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(Naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

参考文献

1. Kang YJ, et al. Br J Pharmacol. 1999 Sep;128(2):357-64.

2. Sun JJ, et al. Life Sci. 2008 Mar 12;82(11-12):600-7.

3. Zhang W, et al. Biochem Pharmacol. 2024 May;223:116112.

4. Oh YJ, et al. Int Immunopharmacol. 2011 Sep;11(9):1160-5.

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