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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium-calcium Exchanger (NCX)-YM-244769
YM-244769

Chemical Structure : YM-244769

CAS No.: 838819-70-8

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YM-244769 (YM244769)

货号: PC-25195Not For Human Use, Lab Use Only.

YM-244769 is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor, inhibits initial rates of 45Ca2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC50 of 68 nM, 96 nM and 18 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YM-244769 is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor, inhibits initial rates of 45Ca2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC50 of 68 nM, 96 nM and 18 nM respectively.
YM-244769 is not only experimentally useful as a NCX inhibitor that preferentially inhibits NCX3, but also has therapeutic potential as a new neuroprotective drug.

物理化学性质&存储条件

分子量 443.48
分子式 C26H22FN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-Aminobenzyl)-6-(4-((3-fluorobenzyl)oxy)phenoxy)nicotinamide

参考文献

1. Iwamoto T, et al. Mol Pharmacol. 2006 Dec;70(6):2075-83.

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