YIAD-1003 (YIAD1003)

Chemical Structure : YIAD-1003

加入收藏

货号: PC-27100Not For Human Use, Lab Use Only.

YIAD-1003 is a multi-isoform small-molecule modulator of pathogenic Aβ aggregation, exhibits significant dose-dependent inhibition and dissociation of both fibrillar and oligomeric Aβ42 species.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

YIAD-1003 is a multi-isoform small-molecule modulator of pathogenic amyloid-β (Aβ) aggregation, exhibits significant dose-dependent inhibition and dissociation of both fibrillar and oligomeric Aβ42 species.
YIAD-1003 inhibited fibril formation and promoted dissociation of preformed aggregates across multiple Aβ isoforms in vitro.
YIAD-1003 exhibits isoform-agnostic inhibitory and dissociative activity against Aβ40, Aβ42, and AβpE3-42
YIAD-1003 exhibits broad-spectrum intervention in Aβ assembly across multiple isoforms and confers functional and pathological benefits in AD mouse models.

物理化学性质&存储条件

分子量	452.45
分子式	C24H25N2O5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	diethyl (2-(benzo[d][1,3]dioxol-5-yl)-3-phenyl-1,2-dihydropyrrolo[1,2-a]pyrazin-1-yl)phosphonate

参考文献

1. Kim J, et al. Alzheimers Res Ther. 2026 Jun 16. doi: 10.1186/s13195-026-02113-5.