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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-YH-0623
YH-0623

Chemical Structure : YH-0623

CAS No.:

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YH-0623 (YH0623)

货号: PC-25138Not For Human Use, Lab Use Only.

YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B.
YH-0623 selectively reduced the expression of mitochondrial genes ND1, CytB, and COX1, while transcripts mediated by nuclear RNA polymerases I, II, and III remained unaffected.
YH-0623 induced a dose-dependent downregulation of specific subunits of respiratory chain complexes encoded by mtDNA, including NDUFB8 (complex I), UQCRC2 (complex III), and COX1 (complex IV).
YH-0623 significantly stabilized POLRMT, specifically targets mitochondrial transcription through POLRMT inhibition.
YH-0623 suppresses mitochondrial-related gene expression by inhibiting mitochondrial transcription.
YH-0623 effectively suppresses 22Rv1 cell proliferation in a concentration-dependent manner.
YH-0623 inhibits cell proliferation through a nonapoptotic and cell cycle-independent mechanism.
YH-0623 inhibits mitochondrial function primarily by suppressing OXPHOS without significantly altering MMP, ROS levels, or glycolytic activity.
YH-0623 (50 mg/kg per day) suppressed 22Rv1 cell xenograft growth in vivo.

物理化学性质&存储条件

分子量 436.48
分子式 C25H25FN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-((R)-2-((6-Fluoro-4-(O-tolyl)quinolin-7-yl)oxy)propanoyl)piperidine-3-carboxylic Acid

参考文献

1. Li X, et al. J Med Chem. 2025 Jul 29. doi: 10.1021/acs.jmedchem.5c00130.

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