YD1701 | ALDH1A3 inhibitor | Probechem Biochemicals

Chemical Structure : YD1701

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YD1701 (YD-1701)

货号: PC-26286Not For Human Use, Lab Use Only.

YD1701 is a specific small molecule inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with MST Kd of 9.8 uM, specifically blocks the enzymatic activity of ALDH1A3 with IC50 of 12.0824 ug/mL.

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生物&药学活性

YD1701 is a specific small molecule inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with MST Kd of 9.8 uM, specifically blocks the enzymatic activity of ALDH1A3 with IC50 of 12.0824 ug/mL.
YD1701 does not inhibit other ALDH enzymes.
YD1701 causes morphological changes linked to the mesenchymal-to-epithelial transition (MET) in CRC cells, attenuates the metastasis of human colorectal cancer.
YD1701 prolongs the survival of mice bearing subcutaneous or orthotopic xenografts.

物理化学性质&存储条件

分子量	536.62
分子式	C28H40O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7,9,10,12,13,15,16,18,19,26,27,29,30,32,33-hexadecahydrodibenzo[b,n][1,4,7,10,13,16,19,22,25,28]decaoxacyclotriacontine

参考文献

1. Jiang-Jie Duan, et al. Cancer Lett. 2022 Jun 28:536:215662.

YD1701 (YD-1701)

生物&药学活性

物理化学性质&存储条件

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YD1701 (YD-1701)

生物&药学活性

物理化学性质&存储条件

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