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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-YCH1899
YCH1899

Chemical Structure : YCH1899

CAS No.: 3032451-66-1

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YCH1899 (YCH-1899)

货号: PC-27879Not For Human Use, Lab Use Only.

YCH1899 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits antiproliferation activity against olaparib- and talazoparib-resistant cells with IC50 of 0.89 and 1.13 nM, respectively.

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5 mg ￥1480 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YCH1899 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits antiproliferation activity against olaparib- and talazoparib-resistant cells with IC50 of 0.89 and 1.13 nM, respectively.
YCH1899 retained sensitivity in drug-resistant cells with BRCA1/2 restoration or 53BP1 loss.
YCH1899 showed prominent dose-dependent antitumor activity in olaparib- and talazoparib-resistant cell-derived xenograft models.
YCH1899 activates type I interferon signaling and synergizes with STING agonists in BRCA-proficient tumors.

物理化学性质&存储条件

分子量 549.35
分子式 C25H18BrFN6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

参考文献

1. Sun Y, et al. J Med Chem. 2023 Sep 14;66(17):12284-12303.

2. Jia L, et al. Mol Biomed. 2026 Aug 26;7(1):151.

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