YC137 | BCL-2 inhibitor | Probechem Biochemicals

Chemical Structure : YC137

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YC137 (YC-137)

货号: PC-25524Not For Human Use, Lab Use Only.

YC137 is a specific small molecule inhibitor of Bcl-2 with Ki of 1.3 uM, with no affinity for Bcl-xL (Ki>100 uM), inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2.

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生物&药学活性

YC137 is a specific small molecule inhibitor of Bcl-2 with Ki of 1.3 uM, with no affinity for Bcl-xL (Ki>100 uM), inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2.
YC137 induced apoptosis of Bcl-2-transfected cells in a dose-dependent manner.
YC137 induces apoptosis in breast cancer cells that express high levels of Bcl-2 but does not have any effect on normal hematopoietic progenitors, peripheral blood mononuclear cells (PBMCs), small intestine epithelial cells, and myoblasts.
Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line.

物理化学性质&存储条件

分子量	511.57
分子式	C24H21N3O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-yl)amino)phenyl (methoxycarbonyl)-L-methioninate

参考文献

1. Nishi R, et al. Cancer Sci. 2013 Apr;104(4):502-7.

2. Real PJ, et al. Cancer Res. 2004 Nov 1;64(21):7947-53.

YC137 (YC-137)

生物&药学活性

物理化学性质&存储条件

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YC137 (YC-137)

生物&药学活性

物理化学性质&存储条件

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