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首页-小分子抑制剂&激动剂-GPCR-Neuropeptide Y Receptor-Y2R antagonist SF-11
Y2R antagonist SF-11

Chemical Structure : Y2R antagonist SF-11

CAS No.: 443292-81-7

Y2R antagonist SF-11 (SF11)

货号: PC-26143Not For Human Use, Lab Use Only.

Y2R antagonist SF-11 is potent, selective and brain penetrant antagonist of Neuropeptide Y Y2 Receptor (Y2R) with IC50 of 199 nM, induces antidepressant-like effect in rats.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Y2R antagonist SF-11 is potent, selective and brain penetrant antagonist of Neuropeptide Y Y2 Receptor (Y2R) with IC50 of 199 nM, induces antidepressant-like effect in rats.

物理化学性质&存储条件

分子量 446.61
分子式 C27H30N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide

参考文献

1. Domin H, et al. ACS Chem Neurosci. 2019 Aug 21;10(8):3454-3463.

2. Brothers SP, et al. Mol Pharmacol. 2010;77(1):46-57.

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