Y041-2712

Chemical Structure : Y041-2712

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货号: PC-24494Not For Human Use, Lab Use Only.

Y041-2712 is a potent, selective CDK8 inhibitor with IC50 value of 398.8 nM, inhibits TGF-β/Smad signaling pathway and the expression of EMT proteins.

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生物&药学活性

Y041-2712 is a potent, selective CDK8 inhibitor with IC50 value of 398.8 nM, inhibits TGF-β/Smad signaling pathway and the expression of EMT proteins.
Y041-2712 shows favorable CDK8 selectivity when tested against a panel of kinases.
Y041-2712 reduced TGF-β1-induced cell migration in a concentration-dependent manner.
Y041-2712 (5 uM) showed a similar reduction in cell migration in TGF-β1-induced A549 cells.
Y041-2712 reduces EMT protein expression and disrupts TGF-β1 signaling.
Y041-2712 exhibited concentration-dependent inhibition of TGF-β1-induced COL1A1 protein expression in WI-38 cells.
Y041-2712 shows potentially impacting the transcription of IPF related protein expression.

物理化学性质&存储条件

分子量	336.39
分子式	C20H20N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-methoxyphenyl)-1H-pyrazol-3-yl)-5-((2-methylallyl)oxy)phenol

参考文献

1. Lin TE, et al. Biochem Pharmacol. 2025 Apr 23:116959.

Y041-2712

生物&药学活性

物理化学性质&存储条件

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Y041-2712

生物&药学活性

物理化学性质&存储条件

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