XYD270 | BRD9 PROTAC | Probechem Biochemicals

Chemical Structure : XYD270

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XYD270 (XYD-270)

货号: PC-26219Not For Human Use, Lab Use Only.

XYD270 is a potent, selective, and orally efficacious BRD9 PROTAC degrader with DC50 of 0.082 nM and 3.9 nM in HS-SY-II cells and MV4;11 cells respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

XYD270 is a potent, selective, and orally efficacious BRD9 PROTAC degrader with DC50 of 0.082 nM and 3.9 nM in HS-SY-II cells and MV4;11 cells respectively.
XYD270 does not reduce BRD4 or BRD7 protein levels.
XYD270 demonstrates potent antiproliferative activity with IC50 values of 50 nM in MV4;11 cells and 1.65 μM in HS-SY-II cells.
XYD270 (10 mg/kg once daily) achieved 54% tumor growth inhibition in MV4;11 xenograft models.

物理化学性质&存储条件

分子量	692.86
分子式	C40H48N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(4-((1-(4-(3-Acetylindolizin-1-yl)-2,6-dimethoxybenzyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)piperidine-2,6-dione

参考文献

1. Huang Y, et al. J Med Chem. 2026 Mar 4. doi: 10.1021/acs.jmedchem.5c02858.

XYD270 (XYD-270)

生物&药学活性

物理化学性质&存储条件

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XYD270 (XYD-270)

生物&药学活性

物理化学性质&存储条件

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