XW-17

Chemical Structure : XW-17

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货号: PC-26590Not For Human Use, Lab Use Only.

XW-17 is a highly potent, selective PARP14 inhibitor with IC50 of 3.03 nM.

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生物&药学活性

XW-17 is a highly potent, selective PARP14 inhibitor with IC50 of 3.03 nM.
XW-17 shows minimal activity against the other tested PARP family members, demonstrating a selectivity index exceeding 9900 over PARP1.
XW-17 induces a concentration-dependent upregulation of PARP14 protein expression, with an EC50 of 59.5 nM in interferon-γ (IFN-γ) stimulated CFPAC-1 cells.
XW-17 inhibits PARP14-mediated ADP-ribosylation in CFPAC-1 and RAW264.7 cell lines.
XW-17 (100 mg/kg) significantly attenuated skin lesions and effectively decreased the expression of key inflammatory factors, including IL-4, IL-13, IgE, and IL-17A, in DNCB-induced AD-like mouse model.

物理化学性质&存储条件

分子量	450.54
分子式	C24H30N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(7-(Cyclopropylmethoxy)-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(1-((1-methyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)acetamide

参考文献

1. Wu S, et al. J Med Chem. 2026 Apr 20. doi: 10.1021/acs.jmedchem.6c00004.

XW-17

生物&药学活性

物理化学性质&存储条件

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XW-17

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物理化学性质&存储条件

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