XL413 | CDC7 inhibitor | Probechem Biochemicals

Chemical Structure : XL413

CAS No.: 1169558-38-6

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XL413 (BMS-863233)

货号: PC-27231Not For Human Use, Lab Use Only.

XL413 (BMS-863233) is a potent, selective, ATP competitive serine/threonine kinase CDC7 inhibitor with IC50 of 3.4 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
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生物&药学活性

XL413 (BMS-863233) is a potent, selective, ATP competitive serine/threonine kinase CDC7 inhibitor with IC50 of 3.4 nM.
XL413 weakly inhibits CK2, PIM1 with IC50 of 215, 42 nM respectively.
XL413 inhibits the cell proliferation (IC50=2685 nM), decreases cell viability (IC50=2142 nM) and elicits the caspase 3/7 activity (EC50=2288 nM) in Colo-205 cells.
XL413 also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC50=715 nM).
XL413 shows cytotoxic effects on tumors, with IC50 of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells.
XL413 demonstrate in vitro CDC7 dependent cell cycle arrest and in vivo tumor growth inhibition in a Colo-205 xenograft model.

物理化学性质&存储条件

分子量	289.72
分子式	C14H12ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one

参考文献

1. Koltun ES, et al. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31.

2. Sasi NK, et al. PLoS One. 2014 Nov 20;9(11):e113300.

3. Jin SF, et al. Exp Cell Res. 2015 Dec 10;339(2):289-99.

XL413 (BMS-863233)

生物&药学活性

物理化学性质&存储条件

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XL413 (BMS-863233)

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