欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclic GMP-AMP synthase (cGAS)-XL-3158
XL-3158

Chemical Structure : XL-3158

CAS No.:

加入收藏

XL-3158 (XL3158)

货号: PC-24705Not For Human Use, Lab Use Only.

XL-3158 is a potent, selective, cross-species, allosteric inhibitor of cyclic GMP-AMP synthase (cGAS), has binding affinity to the catalytic domain of human cGAS (h-cGASCD) with a Kd of 7.19 μM, effectively inhibits cGAS-DNA condensate formation.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XL-3158 is a potent, selective, cross-species, allosteric inhibitor of cyclic GMP-AMP synthase (cGAS), has binding affinity to the catalytic domain of human cGAS (h-cGASCD) with a Kd of 7.19 μM, effectively inhibits cGAS-DNA condensate formation.
XL-3158 inhibits cGAS phase separation in cells.
XL-3158 exhibits an IC50 value of 11.1 μM against h-cGAS and EC0 of 11.85 μM in cellular assays.
XL-3158 potently inhibits cGAS in murine species with IC50 and EC50 values of 2.19 μM and 2.67 μM, respectively, in recombinant m-cGAS and RAW-ISG cells, but not G150.
XL-3158 (25 mg/kg, i.p.) attenuates cerulein-induced acute pancreatitis.

物理化学性质&存储条件

分子量 690.61
分子式 C30H17F7N6O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4'-((4-(trifluoromethyl)phenyl)methylene)bis(1-(4,6-difluorobenzo[d]thiazol-2-yl)-3-methyl-1H-pyrazol-5-ol)

参考文献

1. Zhao W, et al. Nat Commun. 2025 Jun 3;16(1):5140.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: