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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclic GMP-AMP synthase (cGAS)-XL-3156
XL-3156

Chemical Structure : XL-3156

CAS No.:

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XL-3156 (XL3156)

货号: PC-24704Not For Human Use, Lab Use Only.

XL-3156 is a potent, selective, cross-species, allosteric inhibitor of cyclic GMP-AMP synthase (cGAS), targets both the orthosteric and allosteric sites, effectively inhibits cGAS-DNA phase separation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XL-3156 is a potent, selective, cross-species, allosteric inhibitor of cyclic GMP-AMP synthase (cGAS), targets both the orthosteric and allosteric sites, effectively inhibits cGAS-DNA phase separation.
XL-3156 efficiently reduces the h-cGASCD-DNA interactions (EC50=783 nM) as well as phase separation in electrophoretic mobility shift assay (EMSA).
XL-3156 induces a morphological shift of condensates from LSPS to LLPS by reducing the degree of phase separation.

物理化学性质&存储条件

分子量 517.55
分子式 C28H23N9O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4'-(pyridin-2-ylmethylene)bis(1-(1H-benzo[d]imidazol-2-yl)-3-methyl-1H-pyrazol-5-ol)

参考文献

1. Zhao W, et al. Nat Commun. 2025 Jun 3;16(1):5140.

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