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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Porcupine-Wnt-C59
Wnt-C59

Chemical Structure : Wnt-C59

CAS No.: 1243243-89-1

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Wnt-C59 (C59)

货号: PC-25210Not For Human Use, Lab Use Only.

Wnt-C59 (C59) is a highly potent and orally active Porcupine (PORCN) inhibitor, inhibits WNT3A-mediated activation with IC50 of 74 pM.

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10 mg ￥1880 In stock
25 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Wnt-C59 (C59) is a highly potent and orally active Porcupine (PORCN) inhibitor, inhibits WNT3A-mediated activation with IC50 of 74 pM.
C59 inhibits the activity of all splice variants of murine PORCN.
C59 inhibits PORCN acyltransferase activity and blocks activation of all evaluated human Wnts.
C59 blocked progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes. 

物理化学性质&存储条件

分子量 379.46
分子式 C25H21N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

参考文献

1. Proffitt KD, et al. Cancer Res. 2013 Jan 15;73(2):502-7.

2. Cheng Y, et al. Oncotarget. 2015 Jun 10;6(16):14428-39.

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