Withanolide B

Chemical Structure : Withanolide B

CAS No.: 56973-41-2

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货号: PC-26392Not For Human Use, Lab Use Only.

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10 mg	￥4780	In stock
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生物&药学活性

Withanolide B is an active component of W. somnifera Dunal, effectively promotes human bone mesenchymal stem cells (hBMSCs) osteogenic differentiation via ERK1/2 and Wnt/β-catenin signaling pathways, is also a potent AKT modulator.
Withanolide B shows binding affinity toward all AKT isoforms with stable MD trajectories and energetically favorable MM-PBSA profiles, particularly for AKT2.
Withanolide B significantly reduced A549 cell viability (IC50 = 5 μM), induced ROS accumulation, mitochondrial depolarization, chromatin condensation, apoptosis, and S-phase cell cycle arrest.

物理化学性质&存储条件

分子量	454.61
分子式	C28H38O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4AR,4bS,6aR,7R,9aS,9bS,9cS,10aS,10bR)-7-((S)-1-((R)-4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-10b-hydroxy-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,9c,10a,10b-tetradecahydro-4H-cyclopenta[1,2]phenanthro[9,10-b]oxiren-4-one

参考文献

1. Chaurasiya ND, et al. Phytochem Anal. 2008 Mar-Apr;19(2):148-54.

2. Kuang Z, et al. Int Immunopharmacol. 2020 Nov;88:106960.

3. Fatma M, et al. J Ethnopharmacol. 2026 Mar 10;364:121501.

Withanolide B

生物&药学活性

物理化学性质&存储条件

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Withanolide B

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