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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-Withaferin A
Withaferin A

Chemical Structure : Withaferin A

CAS No.: 5119-48-2

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Withaferin A

货号: PC-62155Not For Human Use, Lab Use Only.

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism.

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2 mg ￥1280 In stock
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism.
Withaferin A also is a small molecule that can retard VCP nuclear localization via covalent binding to Cys 158 of KPNB1.
Withaferin A potently inhibits the chymotrypsin-like activity of a purified rabbit 20S proteasome (IC50=4.5 uM) and 26S proteasome in human prostate cancer cultures (at 5-10 uM) and xenografts (4-8 mg/kg/day), inhibits cell proliferation in HUVECs (IC50 =12 nM).
Withaferin A block s VCP nuclear localization to impact on the DDR pathway in vivo.

物理化学性质&存储条件

分子量 470.6
分子式 C28H38O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone

参考文献

1. Falsey RR, et al. Nat Chem Biol. 2006 Jan;2(1):33-8.

2. Kaileh M, et al. J Biol Chem. 2007 Feb 16;282(7):4253-64.

3. Yang H, et al. Mol Pharmacol. 2007 Feb;71(2):426-37.

4. Mohan R, et al. Angiogenesis. 2004;7(2):115-22.
5. Xing Z, et al. Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2416045122.

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