WZS0347 | MITF PROTAC | Probechem Biochemicals

Chemical Structure : WZS0347

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WZS0347 (WZS-0347)

货号: PC-25742Not For Human Use, Lab Use Only.

WZS0347 is a potent, selective first-in-class PROTAC degrader of transcription factor MITF with potency of 78% degradation at 0.1 uM in B16F10 melanoma cells.

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生物&药学活性

WZS0347 is a potent, selective first-in-class PROTAC degrader of transcription factor MITF with potency of 78% degradation at 0.1 uM in B16F10 melanoma cells.
WZS0347 (1 uM) induced concentration-dependent MITF degradation in malignant melanoma cell lines (A375 and GAK).
WZS0347 promoted MITF degradation through a CRBN- and proteasome-dependent pathway.
WZS0347 downregulated MITF and its downstream target genes, suppressing melanoma cell migration.

物理化学性质&存储条件

分子量	790.83
分子式	C41H42N8O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,2'E)-N,N'-(4-((7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)heptyl)amino)pyridine-2,6-diyl)bis(3-(furan-2-yl)acrylamide)

参考文献

1. Shen W, et al. Eur J Med Chem. 2025 Nov 15;302(Pt 3):118367.

WZS0347 (WZS-0347)

生物&药学活性

物理化学性质&存储条件

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WZS0347 (WZS-0347)

生物&药学活性

物理化学性质&存储条件

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