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首页-小分子抑制剂&激动剂-Others-Spliceosome-WX-02-43
WX-02-43

Chemical Structure : WX-02-43

CAS No.: 2929223-36-7

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WX-02-43

货号: PC-27496Not For Human Use, Lab Use Only.

WX-02-43 is a weak covalent inhibitor of SF3B1 and (1S,3R) enantiomer negative control probe of WX-02-23, cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

WX-02-43 is a weak covalent inhibitor of SF3B1 and (1S,3R) enantiomer negative control probe of WX-02-23, cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23.

物理化学性质&存储条件

分子量 459.50
分子式 C26H25N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Propen-1-one, 1-[(1S,3R)-1-(1,3-benzodioxol-5-yl)-1,3,4,9-tetrahydro-3-(4-morpholinylcarbonyl)-2H-pyrido[3,4-b]indol-2-yl]-

参考文献

1. Won SJ, et al. bioRxiv. 2024 Mar 21:2024.03.21.586158.

2. Won SJ, et al. Mol Cell. 2024 Nov 7;84(21):4125-4141.e10.

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