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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-WW-104
WW-104

Chemical Structure : WW-104

CAS No.:

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WW-104 (WW104)

货号: PC-25948Not For Human Use, Lab Use Only.

WW-104 is a specific small molecule USP10 inhibitor with IC50 of 16.75 uM and strong binding affinity with SPR Kd of 237 nM, shows no detectable inhibitory activity against USP7.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

WW-104 is a specific small molecule USP10 inhibitor with IC50 of 16.75 uM and strong binding affinity with SPR Kd of 237 nM, shows no detectable inhibitory activity against USP7.
WW-104 demonstrates potent antiproliferative activity with IC50 of 2.8 uM in Huh-7 cell line.
WW-104 exhibits slightly weaker antiproliferative activity in USP10-overexpressing Huh-6 cell line (IC50=6.29 uM).
WW-104 (5-20 uM) induces the G2 phase arrest and cell apoptosis in Huh-7 cell lines.

物理化学性质&存储条件

分子量 515.99
分子式 C29H26ClN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-chlorophenethyl)-2-(2-(3,4-dihydro-2H-benzo[b][1,4]oxazine-4‑carbonyl)-7-methyl-4-oxoquinolin-1(4H)-yl)acetamide

参考文献

1. Wang W, et al. Bioorg Chem. 2025 Dec 15;169:109348.

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