WRN inhibitor 40

Chemical Structure : WRN inhibitor 40

加入收藏

货号: PC-24739Not For Human Use, Lab Use Only.

WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727.
WRN inhibitor 40 demonstrates selective anti-proliferative activity in WRN dependent cell lines but not in DLD1 cells, with IC50 of 90 nM for SW48 cells.

物理化学性质&存储条件

分子量	788.89
分子式	C40H52F4N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S)-N-((R)-3-Cyclohexyl-1-(dimethylamino)-1-oxopropan-2-yl)-1-(2-(2-fluoro-4-(trifluoromethyl)phenyl)acetyl)-4-(3-(5-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propanamido)piperidine-3-carboxamide

参考文献

1. Yunsong Tong, et al. J Med Chem. 2025 Jun 5. doi: 10.1021/acs.jmedchem.4c03029.

WRN inhibitor 40

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

WRN inhibitor 40

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.